Table 6.
Results from the reverse causation inverse variance weighted two-sample MR analyses.
| Exposure | Odds Ratio [Low 95% CI-High 95% CI] | p | # SNPs | Intercept (SE) | Pleiotropy p | Cochran’s Q | Q_df | Het p |
|---|---|---|---|---|---|---|---|---|
| Myocardial Infarction | 0.93 [0.83–1.05] | 0.248 | 7 | 0.011 (0.035) | 0.766 | 420.82 | 5 | 9.65 × 10−89 |
| Coronary Artery Disease | 0.95 [0.84–1.08] | 0.417 | 38 | 0.006 (0.015) | 0.696 | 6080.02 | 36 | 0.000 |
| Heart Failure | 1.03 [0.98–1.07] | 0.211 | 2 | NA | NA | 0.47 | 1 | 0.495 |
| Atherosclerosis | 1.09 [1.05–1.13] | 2.16 × 10−5 | 1 | NA | NA | NA | NA | NA |
| Hypertensive Heart Disease | 0.99 [0.96–1.03] | 0.728 | 2 | NA | NA | 2.46 | 1 | 0.117 |
Abbreviations: number of SNPs found in the outcome GWAS—# SNPs; MR-Egger intercept (standard error)—Intercept (SE); p-value for the MR-Egger intercept—Pleiotropy p; p-value for the heterogeneity tests performed using the MR-Egger method—Het p.