Figure 5.

Intermittent theta burst stimulation reduces 6-OHDA-induced neuronal death of the lesioned SNpc and loss of TH positive fibers density in the caudoputamen. Representative coronal sections of TH-positive neurons in the SNpc (A) and TH-positive fibers in striatum (B) from sham-treated and iTBS-treated rats after 4 weeks. Scale bar: 500 µm. Representative immunoblot membrane and quantitative data analysis showing relative TH protein abundance in SNpc (C) and caudoputamen (D). Bars represent the mean value of target protein normalized to GAPDH abundance ± SEM (from n = 5 individual animals, in 2–4 technical replicates), expressed relative to left midbrain or caudoputamen, which serves as internal control, arbitrarily defined as 100%. Results of two-tailed unpaired Student’s t-test and significance are shown in graphs: * p < 0.05, *** p < 0.001.