Figure 6.

Intermittent theta burst stimulation modulates NMDA receptor subunit composition. Representative immunoblot membrane and quantitative data analysis showing relative subunit protein abundance of GluN1 (A), GluN2A (B), GluN2B (C), BDNF (D), EAAT1 (E), EAAT2 (F) and GluR1 (G). Relative abundance of the ratio of synaptic proteins Synaptophysin and PSD-95 ratio in caudoputamen of sham and iTBS animals (H). Bars represent the mean value of target protein normalized to GAPDH abundance ± SD (from n = 5–6 individual animals, in 2–4 technical replicates), expressed relative to left caudoputamen, which serves as internal control, arbitrarily defined as 100%. Results of two-tailed unpaired Student’s t-test and significance are shown in graphs: * p < 0.05, ** p < 0.01, *** p < 0.001.