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The compound CAR construction is a two-unit CAR consisting of an entire BCMA-CAR linked to a full CD19-CAR, allowing for the autonomous expression of each of the CAR receptors on the T cell surface. This enables the CAR T cell to target long-lived antibody-producing cells (i.e., CD19+ memory B cells and BCMA+ plasma cells). Red arrows indicate inhibition. The figure was partly created by using www.biorender.com, accessed on 28 May 2023.
