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. 2023 May 25;24(11):9283. doi: 10.3390/ijms24119283

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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QCM-D tracking of SLL hydrolytic cleavage product interactions with supported lipid bilayer (SLB) platform. (A) Molecular structures of SLL and its hydrolytic products, LA and LacA. The resonance frequency (∆f) and energy dissipation (∆D) signals are presented as a function of time for (B) 2000 μM LA + 2000 μM LacA and (C) 1000 μM LA + 1000 μM LacA. The initial baseline values correspond to the DOPC SLB platform, while arrow 1 specifies the time when test compounds were added (t = 5 min) and arrow 2 shows the time when the buffer washing step commenced (t = 65 min).