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. 2023 May 24;12(11):1458. doi: 10.3390/cells12111458

Table 3.

(a,b) Diagnostic performance of plasma NRAS as compared to tissue NRAS.

(a)
	Tissue NRAS
	WT	Mutated	Value (95% CI)
Plasma NRAS
WT	55 (88.7%)	0	Cohen’s K: 0.27 (−0.15–0.68)
Mutated	5 (8.1%)	1 (1.6%)	Sensitivity: 100.0% (2.5–100%)
Mutated	5 (8.1%)	1 (1.6%)	Specificity: 91.7% (81.6–97.2%)
Not Informative	1 (1.6%)	0	PPV: 16.7% (8.0–31.6%)
Not Informative	1 (1.6%)	0	NPV: 100%
(b)
	Tissue NRAS
	Cd12	WT	Concordance
Plasma NRAS
Cd12	1 (1.6%)	2 (3.2%)	Kappa: 0.32 (95% CI: −0.15–0.80); % agreement: 93.4%
Cd61	0	3 (4.8%)
WT	0	55 (88.7%)
Not Informative	0	1 (1.6%)