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. Author manuscript; available in PMC: 2023 Jun 9.
Published in final edited form as: FASEB J. 2023 Feb;37(2):e22727. doi: 10.1096/fj.202201518R

FIGURE 6.

FIGURE 6

Decreased capillarity in ERRα/γ deficient muscle. (A) QPCR analysis of pro-angiogenic (Vegfa, Vegfb, DLL4) and anti-angiogenic gene (Mmp14) expression in DKO versus WT gastrocnemius (N = 5). (B) VEGFA protein levels in DKO versus WT Gastrocnemius (Gast), Quadriceps (Quad), and TA muscles measured by ELISA (N = 3–4). (C) CD31 immunostaining of TA cross-sections (Left panel) and capillary-to-myofiber ratio quantification (Right panel) in DKO compared to WT mice (N = 5). Scale bar (red) = 100 μm. *p < .05, **p < .01, and ***p < .001. Unpaired Student’s t-test.