Table 1.

Differentially expressed genes involved in KEGG Glutamatergic synapse pathway (hsa04724).

Gene	CTRL	Δ8-THC	log2 Fold Change	q-Value	Protein
GLS2	120.39	151.17	0.33	2.38 × 10−2	GLS
GRIA1	494.82	561.49	0.18	1.19 × 10−2	AMPA receptor
GRIA2	1928.70	2098.12	0.12	8.32 × 10−4
GRIA3	1727.64	1915.39	0.15	8.36 × 10−5
GRIA4	541.77	745.06	0.46	1.46 × 10−13
GRIN2C	2.41	13.29	2.46	4.22 × 10−3	NMDA receptor
HOMER2	816.27	1007.53	0.30	6.95 × 10−9	Homer
SHANK3	1790.25	1910.40	0.09	1.52 × 10−2	SHANK
ITPR1	9393.09	9664.99	0.04	1.53 × 10−2	IP3R
ITPR2	1542.24	1645.44	0.09	2.57 × 10−2
PLCB1	1167.82	1269.17	0.12	1.16 × 10−2	PLC
PLD2	1390.54	1577.33	0.18	1.25 × 10−5	PLD
PRKCA	8513.01	9226.42	0.12	1.58 × 10−12	PKC
PRKCG	87.89	136.22	0.63	6.35 × 10−5

For each DEG, the difference in the level of expression computed by log₂(∆⁸-THC/CTRL) results in the log₂ fold change. The post hoc correction of the p-value is highlighted in q-Value column. All values were rounded to the second decimal digit.