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. 2023 May 31;24(11):9596. doi: 10.3390/ijms24119596

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Analysis of receptor repertoire profile of circulating CTL effectors of CLL subjects with stable disease, as compared with healthy controls. Panel (A) shows the expression of KIR2DS2, CD335, CD336, CD337, NKG2D, CD244, 3DL1 and CD85k on the surface of circulating CD8⁺ T-cell effectors of CLL subjects, as compared with controls. As shown, significant increase in the activating KIR2DS2 receptor has been observed. Grey and white columns indicate data obtained in healthy controls (CTR caption of Panel (A)) and CLL individuals (CLL caption of Panel (A)), respectively. Statistical evaluation of data has been performed by means of the Mann–Whitney test. Panels (B) shows the correlation analysis, as evaluated by the Spearman’s test, between the percentage of circulating CD8⁺ T cells expressing CD85k receptor and the HLA-G level on the B lymphocytes of the CLL subjects with stable disease. Statistical significance values are indicated. NS indicates the not statistically significant value. The applied flow cytometry gating strategy is reported in Section 4.2.