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. 2023 May 31;24(11):9533. doi: 10.3390/ijms24119533

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Fecal bacteria composition in Enterotype Lachnospiraceae (ET-L). The distinct differences in the abundance and interactions of specific fecal bacteria between individuals with T2DM and the healthy group within the ET-L enterotype. ET-L participants in the T2DM group had a higher abundance of genera Bacteroides, Phocaeicola, Allistipes, Blautia, Oscillibacter, and Ruminococcus compared to the healthy group. Unlike in ET-B, bacteria in both the T2DM and healthy groups within ET-L exhibited a more stable and positive interaction within each group, with a negative interaction between the T2DM and healthy groups. (A). Relative abundance of fecal bacteria compositions at the genus level between type 2 diabetes (T2DM) and healthy groups. (B). Primary bacteria between the type 2 diabetes (T2DM) and healthy groups at the species level by XGboost in each enterotype. (C). Network of primary bacteria in the T2DM and healthy groups according to each enterotype. Red and blue lines indicate positive and negative correlations with Pearson correlation coefficient >0.1, respectively (p < 0.001). * Significant differences between T2DM and healthy groups at p < 0.00001 (Bonferroni corrected p value).

Fecal bacteria composition in Enterotype Lachnospiraceae (ET-L). The distinct differences in the abundance and interactions of specific fecal bacteria between individuals with T2DM and the healthy group within the ET-L enterotype. ET-L participants in the T2DM group had a higher abundance of genera Bacteroides, Phocaeicola, Allistipes, Blautia, Oscillibacter, and Ruminococcus compared to the healthy group. Unlike in ET-B, bacteria in both the T2DM and healthy groups within ET-L exhibited a more stable and positive interaction within each group, with a negative interaction between the T2DM and healthy groups. (A). Relative abundance of fecal bacteria compositions at the genus level between type 2 diabetes (T2DM) and healthy groups. (B). Primary bacteria between the type 2 diabetes (T2DM) and healthy groups at the species level by XGboost in each enterotype. (C). Network of primary bacteria in the T2DM and healthy groups according to each enterotype. Red and blue lines indicate positive and negative correlations with Pearson correlation coefficient >0.1, respectively (p < 0.001). * Significant differences between T2DM and healthy groups at p < 0.00001 (Bonferroni corrected p value).