In silico determination of pharmacokinetic profiles using SwissADME server.
| No. | MW | H-bond acceptor | H-bond donors | TPSA | WLOGP | GI absorption | BBB permeant | Lipinski #violations | PAINS #alerts |
|---|---|---|---|---|---|---|---|---|---|
| 4a | 319.28 | 6 | 1 | 50.95 | 5.96 | High | No | 0 | 0 |
| 4b | 333.31 | 6 | 1 | 50.95 | 5.88 | High | No | 0 | 0 |
| 4c | 337.27 | 7 | 1 | 50.95 | 6.13 | High | No | 1 | 0 |
| 4d | 297.33 | 4 | 1 | 50.95 | 4.96 | High | Yes | 0 | 0 |
| 4e | 291.23 | 6 | 1 | 50.95 | 5.16 | High | Yes | 0 | 0 |
| 4f | 309.22 | 7 | 1 | 50.95 | 5.72 | High | Yes | 1 | 0 |
| 4g | 309.22 | 7 | 1 | 50.95 | 5.72 | High | Yes | 1 | 0 |
| 4h | 287.26 | 5 | 1 | 50.95 | 4.91 | High | Yes | 0 | 0 |
| 4i | 323.25 | 7 | 1 | 50.95 | 6.21 | High | No | 0 | 0 |
| 4j | 263.25 | 5 | 1 | 87.63 | 2.75 | High | No | 0 | 0 |
| 4k | 266.3 | 4 | 1 | 63.84 | 3.49 | High | Yes | 0 | 0 |
| 4l | 384.15 | 6 | 1 | 50.95 | 6.41 | High | No | 1 | 0 |
| 4m | 347.33 | 6 | 1 | 50.95 | 6.77 | High | No | 1 | 0 |
| 4n | 251.28 | 3 | 1 | 50.95 | 3.79 | High | Yes | 0 | 0 |
| 4o | 269.27 | 4 | 1 | 50.95 | 4.35 | High | Yes | 0 | 0 |