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. 2023 May 29;12(11):3731. doi: 10.3390/jcm12113731

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The evolution of perfusate oxygen concentration, O₂ consumption, and renal flow during hypothermic machine perfusion. To obtain perfusate pO₂ levels above 500 mmHg (at 4 °C), before connecting the kidney to the perfusion device, short bubble oxygenation of minimum 15 min was demonstrated as efficient as membrane oxygenation (a). Both surface-oxygenated groups demonstrated oxygen consumption during the entire preservation period. In contrast, the membrane-oxygenated group demonstrated a decreasing trend of oxygen consumption starting after 2 h of machine perfusion (b). Active oxygenation, independent of the type of oxygen administration technique, demonstrated a comparable renal flow profile during the 22 h of machine perfusion (c).

The evolution of perfusate oxygen concentration, O₂ consumption, and renal flow during hypothermic machine perfusion. To obtain perfusate pO₂ levels above 500 mmHg (at 4 °C), before connecting the kidney to the perfusion device, short bubble oxygenation of minimum 15 min was demonstrated as efficient as membrane oxygenation (a). Both surface-oxygenated groups demonstrated oxygen consumption during the entire preservation period. In contrast, the membrane-oxygenated group demonstrated a decreasing trend of oxygen consumption starting after 2 h of machine perfusion (b). Active oxygenation, independent of the type of oxygen administration technique, demonstrated a comparable renal flow profile during the 22 h of machine perfusion (c).