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Schematic representation of the MDM2 and p53 proteins and the binding areas for small-molecule inhibitors. Examples of small-molecule inhibitors that target the MDM2 protein include nutlin, cis-imidazoline; MI, spiro-oxindoles; and ILN, isoindolinone. By binding to specific areas of the MDM2 protein, these small-molecule inhibitors can effectively inhibit its function, leading to an increase in p53 levels and a reduction in tumor growth.
