Table 3.
Echocardiographic bidimensional (2D-echo), Doppler, and speckle tracking global longitudinal strain (GLS) parameters at baseline and 8 weeks after randomization to diuretics (chlorthalidone + amiloride) or amlodipine.
| Diuretics | Amlodipine | p-Value բ | |||||
|---|---|---|---|---|---|---|---|
| Baseline | Follow-Up | p-Value ∞ | Baseline | Follow-Up | p-Value ∞ | ||
| LVDD (mm) | 47.2 ± 4.4 | 47.1 ± 4.9 | 0.87 | 47.2 ± 5.0 | 47.5 ± 4.8 | 0.58 | 0.63 |
| IVST (mm) | 10.2 ± 1.0 | 9.8 ± 1.1 | 0.04 | 10.7 ± 1.5 | 10.1 ± 2.0 | 0.09 | 0.6 |
| PWT (mm) | 9.3 ± 1.2 | 8.7 ± 1.4 | 0.001 | 9.5 ± 1.3 | 8.6 ± 1.2 | <0.001 | 0.36 |
| LVMI (g/m2) | 80.7 ± 17.7 | 74.6 ± 16.2 | 0.009 | 85.6 ± 18.4 | 78.4 ± 20.0 | <0.001 | 0.72 |
| RWT | 0.40 ± 0.05 | 0.37 ± 0.07 | 0.002 | 0.41 ± 0.06 | 0.37 ± 0.06 | 0.01 | 0.31 |
| EF(%) | 63.6 ± 5.1 | 65.7 ± 5.4 | 0.03 | 63.9 ± 5.4 | 66.6 ± 4.6 | 0.03 | 0.8 |
| LAVI (mL/m2) | 29.4 ± 9.6 | 28.5 ± 8.7 | 0.38 | 31.3 ± 6.6 | 30.9 ± 7.6 | 0.71 | 0.69 |
| LVOT-VTI (cm) | 19.6 ± 3.1 | 19.2 ± 3.7 | 0.46 | 20.3 ± 3.2 | 20.5 ± 3.7 | 0.70 | 0.21 |
| E-wave (cm/s) | 67.6 ± 12.9 | 67.4 ± 13.7 | 0.90 | 69.8 ± 14.4 | 70.4 ± 12.8 | 0.80 | 0.79 |
| A-wave (cm/s) | 65.9 ± 17.6 | 62.2 ± 16.0 | 0.09 | 66.7 ± 19.0 | 67.7 ± 19.7 | 0.68 | 0.15 |
| E/A ratio | 1.11 ± 0.44 | 1.12 ± 0.29 | 0.73 | 1.11 ± 0.34 | 1.10 ± 0.31 | 0.71 | 0.62 |
| Lateral e′ (cm/s) | 11.6 ± 2.7 | 11.9 ± 2.7 | 0.33 | 11.0 ± 2.4 | 10.5 ± 2.5 | 0.21 | 0.12 |
| Septal e′ (cm/s) | 7.6 ± 1.8 | 7.6 ± 1.5 | 1.0 | 7.5 ± 1.9 | 7.5 ± 1.5 | 0.86 | 0.92 |
| Mean E/e′ ratio | 7.26 ± 1.64 | 7.07 ± 1.62 | 0.39 | 7.77 ± 1.89 | 8.1 ± 1.94 | 0.35 | 0.21 |
| LV-GLS (%) | −22.3 ± 3.4 | −23.5 ± 3.4 | 0.034 | −21.5 ± 3.4 | −22.8 ± 3.5 | 0.048 | 0.90 |
| RV-GLS (%) | −25.4 ±5.2 | −25.2 ±3.8 | 0.85 | −24.2 ±3.7 | −24.4 ±3.6 | 0.84 | 0.79 |
Data presented as mean ± SD; ∞ in-group paired t-test comparison; բ independent t-test for comparison of variation differences between groups; LVDD: left ventricular diastolic diameter; IVST: interventricular septal thickness; PWT: posterior wall thickness; LVMI: left ventricular mass index; RWT: relative wall thickness; EF: biplanar Simpson’s ejection fraction; LAVI: biplanar left atrial volume index; LVOT-VTI: left ventricular outflow tract velocity = time integral; E-wave: early mitral peak velocity; A-wave: late (atrial) mitral peak velocity; lateral e′: lateral mitral annulus displacement peak velocity; septal e′: septal mitral annulus displacement peak velocity; LV-GLS: left ventricular global longitudinal strain; RV-GLS: right ventricular global longitudinal strain.