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Interleukin-6 (IL-6) signaling pathways. Il-6 can bind to IL-6 membrane bound receptor (IL-6R), which corresponds to the classic signaling but also to soluble IL-6R (sIL-6R) resulting from limited proteolysis by ADAM proteases. Cells with gp130 can be stimulated by the complex IL-6 and sIL-6R (trans-signaling).
