Figure 6.

Differential patterns predicted by KEGG modules in combinations of anticitrullinated protein antibodies and rheumatoid factor. The abundance of predicted functional modules is shown on the basis of color illumination, where green indicates a decrease in the function parameter, and purple indicates an increase. Trends toward an increase or decrease in the abundance of predicted functions are shown by highlighted arrows. * p < 0.05, ** p < 0.01, *** p < 0.001. The ACPA+/RF− group includes only three samples, so statistical indicators can be both representative and distort the picture associated with characteristic changes.