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. 2023 Jun 5;24(11):9755. doi: 10.3390/ijms24119755

Figure 2.

Figure 2

Mechanism of RNA interference (RNAi). RNAi is initiated by the enzyme Dicer that cleaves double-stranded RNA (dsRNA) into short fragments of approximately 21- to 24-nucleotide short interfering RNA (siRNA). The siRNA is unwound into single-stranded RNA and the sense RNA (green) is further cleaved and degraded by the enzyme Argonaute (AGO). The antisense RNA (red) is recruited into the RNA-induced silencing complex (RISC) that binds to the target sense RNA through the specificity of the complementary antisense RNA.