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. 2023 May 27;24(11):9363. doi: 10.3390/ijms24119363

Figure 2.

Figure 2

Chemical structure of the collected co-crystallized SIRT2 inhibitors as SirReal2 and related analogues. The reference compound is reported within the cyan box; the analogues developed via structural elongation of the prototype are shown in (A). The SirReal2 highly related analogues maintaining the thiazole core are shown in (B), whereas those bearing bioisostere replacement of the thiazole ring are reported in (C). Predicted druglikeness parameters have been reported, as obtained by SWISSADME (TPSA: topological polar surface area) [39].