Table 1.

Retained SIRT2 X-ray structures after exclusion of unsuitable protein–ligand complexes.

Entry	PDB ID	Inhibitor	Cofactor	Substrate	Resolution (Å)	Ref.	Sequence Length	Year
1	1J8F	None	None	None	1.70	[20]	323	2001
2	3ZGV	None	ADPR	None	2.27	[31]	325	2013
3	3ZGO	none	none	None	1.63	[31]	325	2013
4	4RMG	SirReal2	NAD	None	1.88	[22]	304	2015
5	4RMH	SirReal2	None	Ac-Lys-H3 peptide	1.42	[22]	304	2015
6	4RMI	SirReal1	None	Ac-Lys-OTC peptide	1.45	[22]	304	2015
7	4RMJ	Nicotinamide	ADPR	none	1.87	[22]	304	2015
8	5D7P	EX-243	ADPR	None	1.76	[32]	304	2015
9	5D7O	none	ADPR	None	1.63	[32]	310	2015
10	5D7Q	CHIC35	ADPR	None	2.01	[32]	304	2015
11	5DY4	SirReal analog	NAD	None	1.77	[33]	304	2016
12	5DY5	SirReal probe	None	None	1.95	[2]	304	2016
13	5Y5N	Small molecule-inhibitor	None	None	2.30	[34]	336	2017
14	5MAR	oxadiazole	ADPR	None	1.89	[35]	303	2017
15	5MAT	Thienopyrimidinone	None	None	2.07	[35]	303	2017
16	5YQL	A2I	None	None	1.60	[36]	306	2018
17	5YQM	A29	None	None	1.74	[36]	306	2018
18	5YQN	L55	None	None	1.60	[36]	306	2018
19	5YQO	L5C	None	None	1.48	[36]	306	2018
20	5Y0Z	NPD11033	None	None	2.00	[37]	293	2018
21	6QCN	Quercetin (out of the protein)	ADPR	None	2.23	[38]	304	2019