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Inhibition of SIRT2 enzymatic activity. Each compound was tested at the final concentration of 150 μM.
| Molecule | SIRT2 Activity, %Inhibition (at 150 μM) |
|---|---|
| L407-0319 | 44.3 ± 5.3 |
| L929-0391 | 24.4 ± 6.2 |
| S787-1020 | NI |
| T158-0512 | NI |
| G779-0661 | 25.2 ± 5.9 |
| 1 | 81.2 ± 7.3 |
| 2 | 79.9 ± 5.7 |
| 3 | 51.1 ± 15.2 |
| 4 | 35.7 ± 2.5 |
| 5 | 31.4± |
| AGK2 | 97 ± 10 |
NI = No Inhibition.
