Table 2.
Down/upregulated metabolites for comparison between AD and controls.
| Compound | Class | Type | p-Value | FC | log2(FC) | VIP |
|---|---|---|---|---|---|---|
| Hydroxysphingo-myelin C22:1 | sphingolipid | Down | 0.0008 | 0.7728 | −0.3718 | 2.775 |
| Hydroxysphingo-myelin C24:2 | sphingolipid | Down | 0.0024 | 0.7779 | −0.3624 | 2.552 |
| L-Glutamic acid | amino acid | Down | 0.0043 | 0.6142 | −0.7032 | 2.419 |
| Gamma-Aminobutyric acid | amino acid | Down | 0.0089 | 0.8282 | −0.272 | 2.231 |
| Ceramide (d18:1/24:1) | lipid | Up | 0.0133 | 1.1814 | 0.2405 | 2.123 |
| CE (18:2(9Z,12Z)) | lipid | Down | 0.0142 | 0.8273 | −0.2735 | 2.103 |
| L-Aspartic acid | amino acid | Down | 0.0164 | 0.8039 | −0.315 | 2.063 |
| Hydroxysphingo-myelin C22:2 | sphingolipid | Down | 0.0188 | 0.8346 | −0.2608 | 2.023 |
| SM(d18:1/26:0) | sphingolipid | Down | 0.0193 | 0.7856 | −0.3482 | 2.015 |
| L-2-Hydroxyglutaric acid | organic acid | Down | 0.0207 | 0.8858 | −0.175 | 1.993 |
| SM (d18:1/24:0) | sphingolipid | Down | 0.0229 | 0.8416 | −0.2488 | 1.963 |
| Lysophosphatidyl-choline C14:1 | phospholipid | Down | 0.0238 | 0.8017 | −0.319 | 1.951 |
| Homo-L-arginine | amino acid | Down | 0.0296 | 0.7429 | −0.4287 | 1.883 |
| Octadecadienoate | fatty acid derivative |
Down | 0.0321 | 0.6734 | −0.5705 | 1.856 |
| Phosphatidyl-choline aa C28:1 | phospholipid | Down | 0.0355 | 0.8997 | −0.1524 | 1.823 |
| L-Carnitine | amino acid | Down | 0.0438 | 0.8435 | −0.2456 | 1.752 |
| PC aa C40:3 | phospholipid | Up | 0.0486 | 1.2641 | 0.3381 | 1.716 |
Legend: CE = cholesteryl ester; SM = sphingomyelin; PC = phosphatidylcholine.