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The effect of 48 h of incubation of irinotecan (5 μM and 20 μM), melatonin (2000 µM), wogonin (25 μM), celastrol (0.625 μM and 1.25 μM), and their combinations with LOVO cells on the percentage gap closure. The results are shown as the mean ± SD of five independent experiments. The significance of the differences was determined by the Mann–Whitney U test. * p < 0.05, ** p < 0.01. Abbreviations: Iry (irinotecan), Mel (melatonin), Cel (celastrol), Wog (wogonin).
