Table 1.

Combination of drugs with the highest level of dead cells. Abbreviations: Iry (irinotecan), Mel (melatonin), Cel (celastrol), Wog (wogonin).

Irinotecan and Melatonin Alone	Percentage of Dead Cells
	LOVO Cells	LOVO/DX Cells
IRY 5 µM	36%	30%
IRY 20 µM	55%	50%
MEL 2000 µM	47%	44%
Combination of drugs
IRY 20 µM + CEL 0.625 µM	69%	70%
IRY 20 µM + CEL 1.25 µM	84%	79%
IRY 20 µM + WOG 25 µM	75%	63%
IRY 20 µM + WOG 50 µM	75%	72%
MEL 2000 µM + IRY 5 µM	57%	55%
MEL 2000 µM + IRY 20 µM	61%	55%
MEL 2000 µM + CEL 0.625 µM	58%	53%
MEL 2000 µM + CEL 1.25 µM	83%	72%
MEL 2000 µM + WOG 25 µM	62%	47%
MEL 2000 µM + WOG 50 µM	78%	78%