Table 3.
Results of combined drugs in the scratch assay. Abbreviations: Iry (irinotecan), Mel (melatonin), Cel (celastrol), Wog (wogonin).
| Irinotecan or Melatonin Alone | Gap Closure | |
|---|---|---|
| LOVO Cells | LOVO/DX Cells | |
| IRY 5 µM | 47.6% | 23.1% |
| IRY 20 µM | −2.2% * | 3.4% |
| MEL 2000 µM | 57.0% | 36.0% |
| Combination of Drugs | ||
| IRY 5 µM + WOG 25 µM | −0.3% * | 19.2% |
| IRY 5 µM + MEL 2000 µM | 48.2% | 30.8% |
| IRY 20 µM + WOG 25 µM | −2.9% * | 1.7% |
| IRY 20 µM + CEL 0.625 µM | 0.6% | 4.5% |
| IRY 20 µM + CEL 1.25 µM | −1.0% * | 4.7% |
| MEL 2000 µM + WOG 25 µM | 25.0% | 7.7% |
| MEL 2000 µM + CEL 0.625 µM | 59.1% | 36.3% |
| MEL 2000 µM + CEL 1.25 µM | 56.5% | 32.9% |
* Results with a negative number showed that the gap increased after 48 h of treatment.