Figure 4.

Levels of social structure and framework to optimize clinical studies in OA. There is an urgent need to well inform individuals and the community to strictly adhere to the proposed diet regimen, to ensure more rigorous studies and avoid the possibility of risk bias in interpreting clinical results. The health system needs synergistic cooperation between health professionals to identify novel food alternatives and develop personalized medicine through the use and integration of different analyses. Indeed, on global level, more safety controls on PUFA formulations, searches for dietary alternatives rich in n-3 PUFAs and more rigorous clinical studies are necessary.