Figure 5.

Schematic representation of measures to close gaps and create new opportunities in using polyunsaturated fatty acids in Ob-associated OA. Safety and lack of availability are the major limitations of using these phytochemicals. Safety issues mainly include aspects of chemical instability that cause the generation of toxic products, both systemically and locally. The presence of contaminants in n-3 PUFA-rich foods predisposes various side effects. New opportunities to optimize the use of PUFAs lie in improving their stability and establishing new treatment options to improve clinical success rates.