Figure 5.

Analysis of the substrate contribution of mitochondrial respiration in tissue biopsies of transplanted DBD and DCD livers pre-NMP, at 1 h and at the end of NMP, and post-reperfusion. Flux control ratios (FCR) were calculated to assess the relative contribution of the three substrate pathways to the maximum OXPHOS capacity for DBD (A) and DCD (B) livers. Values are represented as the median and interquartile range. (** p < 0.05, ANOVA tests between time points and between the groups; details are described in the section on statistical analysis). NMP, normothermic machine perfusion; h, hour; DBD, donation after brain death; DCD, donation after circulatory death; S, succinate-linked respiration; F, fatty acid oxidation-linked respiration; N, NADH-linked respiration.