Figure 7.

Analysis of succinate-linked mitochondrial respiration in tissue biopsies of transplanted DBD and DCD livers with initial function or early allograft dysfunction pre-NMP, at 1 h and at the end of NMP, and post-reperfusion. (A,B) OXPHOS capacity, (C,D) P-L control efficiency, (E,F) LEAK respiration and (G,H) cytochrome c control efficiency were measured and calculated following the protocol as described in Table S2. Results are shown as individual values and medians for DBD (solid circles) and DCD (open boxes) livers. IF, initial function; EAD, early allograft dysfunction; NMP, normothermic machine perfusion; h, hour; DBD, donation after brain death; DCD, donation after circulatory death.