Table 6.

Perfusate cytokine levels of declined DBD and DCD livers at 1 h NMP and at the end of NMP.

Cytokine [Median (IQR)]	DBD (n = 5)	DCD (n = 6)	p Value
IL-4
1 h	13.12 (2.04–25.03)	11.97 (7.20–13.12)	0.6087
end	<LOD	<LOD
IL-12 p70
1 h	6.26 (3.07–9.35)	5.30 (4.41–6.99)	0.7698
end	0.95 (0.54–2.34)	0.47 (0.27–1.29)	0.8650
IL-13
1 h	7.07 (2.49–13.20)	6.40 (5.34–9.71)	0.9517
end	3.95 (2.31–6.08)	2.32 (1.25–3.46)	0.5671
GM-CSF
1 h	25.60 (13.72–42.86)	18.59 (10.62–28.35)	0.0742
end	5.13 (3.91–5.13)	6.43 (4.64–7.92)	0.9334
TNFα
1 h	12.68 (6.06–23.08)	11.20 (8.58–14.52)	0.7346
end	10.01 (7.69–16.67)	8.63 (4.66–11.10)	0.5032
IFNγ
1 h	11.45 (6.54–27.20)	13.49 (9.84–20.56)	0.9996
end	23.04 (17.06–105.64)	9.01 (4.04–27.73)	0.1873
IL-1β
1 h	9.01 (5.91–17.11)	5.08 (3.13–7.81)	0.8415
end	53.74 (16.39–78.18)	11.23 (5.22–28.02)	0.0118
IL-2
1 h	21.44 (10.87–28.98)	15.50 (8.26–17.62)	0.4303
end	6.91 (6.50–10.45)	9.48 (6.01–25.13)	0.5223
IL-5
1 h	3.37 (0.92–3.94)	1.85 (0.82–3.68)	0.9940
end	5.24 (4.78–7.97)	5.40 (4.23–14.55)	0.3620
IL-6
1 h	1172.95 (243.10–2229.94)	458.2 (411.10–657.10)	0.9674
end	7829.01 (2559.54–18,138.94)	5938.39 (3702.15–13,128.94)	0.6633
IL-18
1 h	408.91 (236.60–1384.93)	602.36 (393.23–1380.35)	0.9828
end	1147.04 (1097.29–3737.42)	655.43 (425.82–962.11)	0.0426

NMP, normothermic machine perfusion; LOD, limit of detection; IL, Interleukin; GM-CSF, granulozyte-monozyte colony-stimulating factor; TNFα, tumor necrosis factor alpha; IFNγ, interferon gamma; DBD, donation after brain death; DCD, donation after circulatory death; h, hour; IQR, interquartile range.