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Inhibitory activities of compounds 126a–122i against kinases.
| |||||
|---|---|---|---|---|---|
| Compd. | R1 | R2 | IC50 (nM) | ||
| c-KIT | PDGFRα | VEGFR2 | |||
| 126a |
|
|
2.4 | 87 | 4920 |
| 126b |
|
|
3.7 | 32 | 3360 |
| 122g |
|
|
>50,000 | >50,000 | >50,000 |
| 122h |
|
|
6768 | >50,000 | >50,000 |
| 122i |
|
|
3.9 | 22 | 1208 |
