Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
SAR overview for six-position imidazopyridine modifications.
| Compd. | Structure | IC50 [nm] | Cell IC50 [nm] | Clint HLM/MLM |
Solubility [µM] |
|---|---|---|---|---|---|
| IX |
|
13 | 300 | h/h | 81 |
| X |
|
12 | 110 | h/h | 9 |
| XI |
|
11 | 290 | m/h | 100 |
| XII |
|
4.6 | 160 | m/L | <2 |
| XIII |
|
8.6 | 55 | m/L | <2 |
| 135a |
|
7.3 | 48 | m/h | <2 |
