. 2023 May 29;24(11):9450. doi: 10.3390/ijms24119450

Table 23.

Antiproliferative activities of thiazolo[5,4-b]pyridine derivatives.

Compd.	GI₅₀ (µM) ^a		Entry	GI₅₀ (µM) ^a
Compd.	GIST-T1	HMC1.2	Entry	GIST-T1	HMC1.2
imatinib	0.02 ± 0.01	27.10 ± 3.36	142p	0.66 ± 0.10	8.55 ± 2.40
sunitinib	0.01 ± 0.00	2.53 ± 0.35	142q	0.42 ± 0.07	15.53 ± 3.97
142a	>50	Inactive ^b	142r	0.01 ± 0.00	1.15 ± 0.96
142b	33.05 ± 7.09	Inactive ^b	142s	0.02 ± 0.00	1.33 ± 0.43
142c	33.69 ± 3.45	Inactive ^b	142t	0.12 ± 0.03	6.62 ± 0.75
142d	16.36 ± 2.73	25.18 ± 2.21	142u	0.66 ± 0.08	11.31 ± 0.34
142e	3.45 ± 0.41	11.53 ± 0.62	142v	0.05 ± 0.01	6.81 ± 0.67
142f	20.94 ± 2.00	Inactive ^b	142w	0.02 ± 0.01	4.99 ± 0.43
142g	10.84 ± 1.06	36.77 ± 10.9	143a	0.08 ± 0.01	4.58 ± 0.32
142h	0.96 ± 0.10	7.26 ± 4.13	143b	0.10 ± 0.01	5.22 ± 0.59
142i	7.16 ± 0.87	9.65 ± 1.06	143c	0.01 ± 0.00	1.52 ± 0.43
142j	3.31 ± 0.73	6.35 ± 0.32	143d	8.13 ±1.81	Inactive ^b
142k	0.18 ± 0.03	2.27 ± 0.84	143e	0.23 ± 0.07	14.04 ± 10.2
142l	0.08 ± 0.01	4.34 ± 1.31	143f	0.30 ± 0.06	28.39 ± 13.3
142m	0.27 ± 0.17	3.41 ± 1.49	143g	0.07 ± 0.01	4.88 ± 1.18
142n	0.55 ± 0.09	7.00 ± 2.68	143h	0.02 ± 0.00	4.98 ± 0.32
142o	0.28 ± 0.08	2.36 ± 0.58

^a Radiometric biochemical kinase assay results. ^b less than 50% inhibition at a concentration of 10 µM.