Table 1.
Lethal and morbid effects of pit viper venoms and their neutralisation by Indian and Sri Lankan antivenoms. In this table, the LD50 for H. hypnale, along with the range-finding values of LD50 for C. malabaricus and C. gramineus, are indicated in mg/kg. The estimates of MHD (μg/mouse) and MND (μg/mouse) for H. hypnale and/or C. malabaricus are also indicated. The amount of undiluted antivenom required to neutralise the lethal and morbid effects is indicated. NA—Not available; Value could not be estimated given insufficient neutralisation; PSVPL (Premium Serums and Vaccines Pvt Ltd.)-IN (Indian) and SL (Sri Lankan).
| C. malabaricus | C. gramineus | H. hypnale | ||
|---|---|---|---|---|
| LD50 mg/kg | >6 | 4–6 | 1.32 | |
| MHD (μg/mouse) | 0.365 | NA | 2.32 | |
| MND (μg/mouse) | NA | NA | 22.3 | |
| ED50 (mL) | PSVPL-IN | NA | NA | — |
| PSVPL-SL | NA | NA | — | |
| MHD50 (mL) | PSVPL-IN | 3.6 × 10−4 | NA | — |
| PSVPL-SL | 3.4 × 10−4 | NA | — | |
| MND50 (mL) | PSVPL-IN | NA | NA | — |
| PSVPL-SL | NA | NA | — | |