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. 2023 May 29;24(11):9445. doi: 10.3390/ijms24119445

Figure 5.

Figure 5

The pro-epileptic effect of alpha2-agonist Dexmedetomidine in rats with spontaneous SWDs. (a) Example of SWDs and power spectrum recorded during baseline and 5 min after i.p. injection of Dexmedetomidine (0.011 mg/kg) in rat ID = W7. The frontal left EEG signal was visualized in LabChart v. 8.1.160. The bottom graph shows the FFT power spectrum computed with 1024 size and 95.5% window overlap. SWDs (white arrows) are seen as high-voltage bursts in raw EEG and 8–10 Hz activity in the power spectrum. (b) Scores of the differential density of SWDs (the difference between dSWD after Dex injection and in baseline in% from 5 min) in 13 rats (27 tests, 1–3 tests per rat). Results of K-means cluster analysis; asterisks mark 5-min intervals, in which differences between clusters were significant with p < 0.05.