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. 2023 May 29;24(11):9445. doi: 10.3390/ijms24119445

Table 1.

The literature data on alpha2-agonist dexmedetomidine (Dex) effects on spike-wave discharges (SWDs) in rats.

Rout Dose Effect Rats Reference
i.p. 1 mg/kg,
acute		 Injection of Dex in a very high dose (1 mg/kg) elicited:

  1. Decrease in the total number of SWDs during 40–120 min after injection.

  2. No differences in the mean duration of SWDs

 WAG/Rij rats
6–7 months old, male		 Al-Gailani et al., 2022 [38]
i.c.v. 0.1, 0.5, 2.5 µg, acute Injection of 2.5 µg led to an enhancement of SWDs:

  1. Increase in the total duration of SWDs on 20, 40 and 60 min after treatment.

  2. Increase in the number of SWDs on 60 and 80 min after treatment.

  3. Increase in the mean duration of SWDs on 40 and 60 min after treatment.

Injection of 0.5 µg led to an enhancement of SWDs:

  1. Increase in the total duration of SWD 20 min after treatment.

  2. Increase in the mean duration of SWD 20 min after treatment

 GAERS
3–4 months old, male		 Yavuz et al., 2022 [23]
i.p. 0.005 mg/kg,
acute		 Injection of a very low dose (0.005 mg/kg) increased the incidence of HVS 2 h after injection. Wistar
10–12 months old, male		 Yavich et al., 1994 [26]

Abbreviations: HVS—high voltage spindles (similar to spike-wave discharges), SWDs—spike-wave discharges; GAERS—genetic absence epilepsy rats from Strasbourg. Type of administration: i.p.—intraperitoneal, i.c.v.—intracerebroventricular.