Table 1.
Summary of the studies of in vivo use of silk fibroin grafts in the different animal models.
| Graft composition | Graft inner diameter | Animal model | Implantation site | Implantation time | Author, year |
|---|---|---|---|---|---|
| Braided SF | 1.5 mm | Sprague-Dawley Rats | Aorta | 18 months | Enomoto et al., 2010 |
| Electrospun SF | 1.5 mm | Sprague-Dawley Rats | Aorta | 3, 6, 12, 24 weeks | Filipe et al., 2018 |
| Electrospun SF | 1.5 mm | Lewis Rats | Aorta | 1 week | Cattaneo et al., 2013 |
| Gel-spun SF | 1.0–1.5 mm | Sprague-Dawley Rats | Aorta | 1, 3, 6 months | Rodriguez et al., 2019 |
| Double Raschel-knitted TG-SF | 1.5 mm | Sprague-Dawley Rats | Aorta | 2 weeks | Asakura et al., 2014 |
| Double Raschel-knitted TG-SF | 1.5 mm | Sprague-Dawley Rats | Aorta | 2, 4, 8 weeks | Saotome et al., 2015 |
| Computer-controlled braided TG-SF | 1.5 mm | Sprague-Dawley Rats | Aorta | 2 weeks; 3 months | Fukuyama et al., 2017 |
| Braided SF | 0.9 mm | C57BL/6 Mice | Carotid Artery | 1, 2, 4 weeks; 3, 6 months | Tanaka et al., 2020 |
| Dip-coated SF/gelatin patches + Simvastatin micelles | N/A | F344 Rats | Carotid Artery | 2 weeks | Thitiwuthikiat et al., 2015 |
| Electrospun PCL/SF + VEGF + Heparin | 1 mm | Rats | Carotid Artery | 3, 4, 6 weeks | Yue et al., 2022 |
| Electrospun PCL/SF + Spirulina | * | Rats | Carotid Artery | 3 weeks | Kim et al., 2015 |
| Double Raschel-knitted PET + SF(Glyc) Coating | 1.5 mm | Sprague-Dawley Rats | Aorta | 2 weeks; 3 months | Tanaka et al., 2020 |
| Double Raschel-knitted SF + SF Coating | 1.5 mm | Sprague-Dawley Rats | Aorta | 2 weeks; 3 months | Fukuyama et al., 2015 |
| Double Raschel-knitted SF + SF/PDGE Coating | 1.5 mm | Sprague-Dawley Rats | Aorta | 3 weeks; 3 months | Fukuyama et al., 2015 |
| Double Raschel-knitted SF + SF Coating | 1.5 mm | Sprague-Dawley Rats | Aorta | 2, 8 weeks | Yagi et al., 2011 |
| Electrospun SF/PU Patches | N/A | Sprague-Dawley Rats | Aorta | 1, 3, 6 months | Chantawong et al., 2017 |
| Dip-coated SF Stents | 1 mm | Sprague-Dawley Rats | Aorta | 16 weeks | Smeets et al., 2016 |
| Braided SF + SF Coating | 3 mm | NZ White Rabbits | Carotid Artery | 2 weeks; 2, 3, 6, 12 months | Li et al., 2019 |
| Electrospun PLCL/SF + Heparin | 2 mm | NZ White Rabbits | Carotid Artery | 2 weeks; 1, 2, 3 months | Jin et al., 2019 |
| SF-coated ePTFE | 4 mm | NZ White Rabbits | Aorta | 3 months | Zhang et al., 2017 |
| SF-impregnated Dacron | 8 mm | Mongrel Dogs | Aorta | 4 h; 3 days; 2 weeks; 1, 3, 6 months | Huang et al., 2008 |
| Electrospun SF/TPU Patches | N/A | Beagle Dogs | Aorta | 3 months | Shimada et al., 2017 |
| Double Raschel-knitted SF + SF Coating | 3 mm | Beagle Dogs | Carotid Artery | 4 weeks; 12 months | Aytemitz et al., 2013 |
| Double Raschel-knitted SF + SF Coating | 3.5 mm | Beagle Dogs | Carotid Artery | 1, 2, 3 days; 1, 2, 3 weeks; 1–7 months | Haga et al., 2017 |
| Chitosan-sulfated SF | * | Beagle Dogs | Femoral Artery | 6 months | Ma et al., 2017 |
| Double Raschel-knitted SF + SF Coating | 3.5 mm | Beagle Dogs | Femoral Artery | 3, 5, 12 months | Tanaka et al., 2021 |
| SF/Heparin/Clopidrogrel-coated Metallic Stents | 6 mm | Yorkshire Swine | Aorta | 2.5 h | Wang et al., 2008 |
| Electrospun SF/PCU | 6 mm | Sheep | Carotid-Jugular AV Shunt | 1, 2, 3 months | Riboldi et al., 2020 |
| Electrospun SF/TEX | 5 mm | Sheep and Minipig | Carotid Artery | 1 month | Alessandrino et al., 2019 |
*
Not present in the paper.