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. 2023 Jun 4;28(11):4544. doi: 10.3390/molecules28114544

Figure 1.

Figure 1

Schematic representation of the full-length Tau protein. N1 and N2, and R1–R4 represent the N-terminal and C-terminal inserts, respectively. According to the different RNA splicings, Tau can be expressed as 4R2N (Tau with N1, N2, R1, R2, R3, and R4 insertions), 4R1N (Tau with N1, R1, R2, R3, and R4 insertions), 4R0N (Tau with R1, R2, R3, and R4 insertions), 3R2N (Tau with N1, N2, R1, R3, and R4 insertions), 3R1N (Tau with N1, R1, R3, and R4 insertions), 3R0N (Tau with R1, R3, and R4 insertions). 0N, 1N and 2N isoforms represent around the 40%, 50%, and 10% of all Tau isoforms, respectively [23,24,25], PHF6 (VQIVYK) and PHF6* (VQIINK) are the regions of the protein involved in the formation of Tau aggregates [26]. K18 and K19 constructs of Tau including R1 to R4, R1, R3, and R4 insertions are also shown as red and blue bars, respectively. The full-length amino acids sequence of Tau, including phosphorylating sites (highlighted in yellow), is also reported [7,25].