Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 2;11(6):e006388. doi: 10.1136/jitc-2022-006388

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Expression of ASS1 improves MYXV-based OV. (A) Genomic schematic of recombinant viruses used in this study including MyxPD1/IL-12 and MyxASS1/PD1/IL-12. (B, C) ASS1^WT, ASS1^KO (KO#1 and KO#4), and A9F1 tumors were established in C57Bl/6J mice and then treated with three doses of either PBS (mock) or 1×10⁵ FFU of MyxPD1/IL-12 or MyxASS1/PD1/IL-12 intratumorally QOD over 5 days. Tumor burden was then monitored QOD in all cohorts. (B) Spaghetti plots tracking individual tumor sizes over time. (C) Overall survival of mice. Statistical significance was determined using log-rank analysis (n=6–9 mice per group). *P<0.05. ASS1, argininosuccinate synthetase 1; IL, interleukin; MyxASS1, MYXV encoding full-length murine ASS1; MYXV, myxoma virus; OV, oncolytic virotherapy; PBS, phosphate-buffered saline; QOD, every other day; WT, wild type.