Table 1.
Baseline characteristics of study cohort (N=9683)
| eRSVP 0.00–29.99 n=959 |
eRVSP 30.00–39.99 n=2952 |
eRVSP 40–49.99 n=3167 |
eRVSP 50–59.99 n=1588 |
eRVSP >60.00 n=1017 |
P value | |
| Demographics | ||||||
| Age, years | 69±17 | 74±13 | 78±11 | 81±10 | 80±11 | < 0.0001 |
| Female (%) | 611 (63.7) | 1773 (60.1) | 1992 (62.9) | 1011 (63.7) | 651 (64.0) | <0.0001 |
| Anthropometrics | ||||||
| BMI | 25.92±5.15 | 26.02±5.40 | 26.52±5.76 | 26.56±6.03 | 26.05±5.73 | 0.48 |
| BSA | 1.80±0.24 | 1.80±0.24 | 1.80±0.25 | 1.80±0.24 | 1.76±0.24 | <0.0001 |
| Rhythm | ||||||
| Atrial fibrillation/arrhythmia | 230 (24.0) | 947 (32.1) | 1268 (40.0) | 770 (48.5) | 557 (54.8) | <0.0001 |
| LV dimensions and function | ||||||
| LVEF % | 66.14±5.41 | 68.13±6.89 | 70.53±7.90 | 70.40±7.89 | 70.02±7.90 | <0.0001 |
| Stroke volume index (mL/m2) | 44.06±11.97 | 44.98±14.37 | 44.96±14.79 | 43.49±14.09 | 42.15±14.99 | 0.06 |
| E:e′ ratio | 12.90±5.63 | 13.07±5.68 | 14.14±5.27 | 15.35±5.51 | 17.16±7.01 | <0.0001 |
| LVEDD | 4.50±0.67 | 4.71±0.69 | 4.87±0.73 | 4.92±0.77 | 4.85±0.82 | <0.0001 |
| LVESD | 2.87±0.53 | 2.87±0.57 | 2.84±0.64 | 2.87±0.65 | 2.83±0.69 | 0.009 |
| Atrial dimensions | ||||||
| LA volume index, mL/m2 | 43.84±24.23 | 67.90±41.04 | 95.53±47.82 | 108.92±54.28 | 108.95±55.95 | <0.0001 |
| RA area, cm2 | 18.18±7.25 | 24.21±8.76 | 29.03±8.50 | 32.12±9.01 | 33.71±9.35 | <0.0001 |
| Right heart dimensions and function | ||||||
| eRSVP, mm Hg | 25.66±3.63 | 35.43±2.94 | 44.69±2.76 | 53.97±2.93 | 71.10±10.84 | <0.0001 |
| TR peak velocity, m/s | 2.19±0.23 | 2.56±0.17 | 2.94±0.14 | 3.30±0.14 | 3.86±0.33 | <0.0001 |
| RV basal diameter | 3.53±0.75 | 3.30±0.47 | 3.36±0.37 | 3.44±0.40 | 3.56±0.47 | <0.0001 |
| Dilated RV | 95 (9.9) | 509 (17.2) | 1051 (33.2) | 673 (42.4) | 521 (51.2) | <0.0001 |
| Impaired RV function | 14 (1.5) | 28 (0.9) | 59 (1.9) | 54 (3.4) | 82 (8.1) | <0.0001 |
| Mitral valve dimensions and function | ||||||
| MV mean gradient, mm Hg | 2.32±1.18 | 2.63±1.20 | 3.01±1.16 | 3.31±1.18 | 3.09±1.22 | <0.0001 |
| Concomitant valvular pathology | ||||||
| Moderate or greater aortic regurgitation | 85 (8.9) | 246 (8.3) | 369 (11.7) | 229 (14.4) | 156 (15.3) | <0.0001 |
| Severe AS <1 cm2 | 26 (2.7) | 89 (3.0) | 121 (3.8) | 82 (5.2) | 77 (7.8) | <0.0001 |
Values are n (%) unless otherwise indicated.
AS, aortic stenosis; AV, aortic valve; BMI, body mass index; BSA, body surface area; eRVSP, estimated right ventricular systolic pressure (mm Hg); LA, left atrial; LV, left ventricle; LVEDD, left ventricular end diastolic diameter; LVEF, left ventricular ejection fraction; LVESD, left ventricular end systolic pressure; MV, mitral valve; RA, right atrial; RV, right ventricle; TR, tricuspid regurgitant; VTI, velocity time integral.