Table 2.
Association of XL9 variants with SLE
| Genotype | Effect allele | Additive model | |||||
| P value | FDR Q* | OR (95% CI) | |||||
| rs9271375A/G | A/A | A/G | G/G | A | |||
| SLE (n=442) | 39 (8.8) | 172 (38.9) | 231 (52.3) | 250 (28.3) | 0.051 | 0.051 | 0.84 (0.70 to 1.00) |
| Controls (n=779) | 78 (10.0) | 344 (44.2) | 357 (45.8) | 500 (32.1) | Referent | ||
| rs9271378G/A | G/G | G/A | A/A | G | |||
| SLE (n=442) | 7 (1.6) | 84 (19.0) | 351 (79.4) | 98 (11.1) | 0.038 | 0.051 | 0.77 (0.59 to 0.98) |
| Controls (n=779) | 16 (2.1) | 187 (24.0) | 576 (73.9) | 219 (14.1) | Referent | ||
| rs2105898T/G | T/T | T/G | G/G | T | |||
| SLE (n=442) | 48 (10.9) | 174 (39.4) | 220 (49.8) | 270 (30.5) | 0.0017 | 0.0067 | 1.34 (1.12 to 1.61) |
| Controls (n=779) | 46 (5.9) | 291 (37.4) | 442 (56.7) | 383 (24.6) | Referent | ||
| rs9271593C/T | C/C | C/T | T/T | C | |||
| SLE (n=442) | 63 (14.3) | 202 (45.7) | 177 (40.0) | 328 (37.1) | 0.018 | 0.037 | 1.23 (1.04 to 1.46) |
| Controls (n=779) | 83 (10.7) | 338 (43.4) | 358 (46.0) | 504 (32.3) | Referent | ||
*Significance level was set at FDR Q<0.05.
FDR, false discovery rate; SLE, systemic lupus erythematosus.