Table 5.
HRs associated with low and high serum metals all-cause mortality (all sites combined).
| Total /Deaths |
Age-Adjusted Only | Adjusted | |
|---|---|---|---|
| HR (95%CI) p-Value | HR (95%CI) p-Value | ||
| Selenium | |||
| Low | 484/250 | 2.18 (1.81–2.62) < 0.0001 | 1.61 (1.28–2.02) < 0.0001 |
| Middle | 702/206 | 1.0 | 1.0 |
| High | 289/58 | 0.66 (0.49–0.88) 0.005 | 0.71 (0.52–0.96) 0.03 |
| Zinc | |||
| Low | 473/224 | 1.68 (1.40–2.01) < 0.0001 | 1.19 (0.97–1.47) 0.10 |
| Middle | 737/240 | 1.0 | 1.0 |
| High | 265/50 | 0.55 (0.41–0.75) 0.0001 | 0.72 (0.52–0.99) 0.04 |
| Copper | |||
| Low | 406/115 | 0.86 (0.69–1.33) 0.19 | 0.81 (0.64–1.01) 0.07 |
| Middle | 746/239 | 1.0 | 1.0 |
| High | 323/160 | 1.91 (1.56–2.08) < 0.0001 | 1.72 (1.41–2.11) < 0.0001 |
| Current Smoker | |||
| No | 641/183 | 1 | 1 |
| Yes | 676/278 | 1.77 (1.46–2.13) < 0.0001 | 0.97 (0.76–1.25) 0.83 |
| Missing | 158/53 | 1.11 (0.81–1.51) 0.51 | 1.46 (0.99–2.15) 0.06 |
| Sex | |||
| Female | 681/214 | 1 | 1 |
| Male | 794/300 | 1.28 (1.06–1.53) 0.009 | 1.21 (0.91–1.60) 0.18 |
Adjusted model adjusted for age, sex and current smoking status in addition to the other elements and cancer sites.