Table 1.
Exposure | Outcome (Breast Cancer) |
Number of IVs | p | OR (95%CI) | Cochran’s Q Test | MR-Egger Intercept Test |
---|---|---|---|---|---|---|
Relative intake of carbohydrate | Overall | 6 | 0.19 | 1.26 (0.89–1.80) | 0.16 | 0.41 |
Luminal A | 5 | 1.79 × 10−2 | 1.61 (1.09–2.40) | 0.44 | 0.76 | |
Luminal B | 7 | 0.14 | 2.07 (0.78–5.50) | 0.14 | 0.04 | |
Luminal B HER2-negative | 8 | 0.87 | 0.95 (0.49–1.83) | 0.34 | 0.64 | |
HER2-positive | 8 | 0.89 | 1.10 (0.27–4.55) | 0.07 | 0.91 | |
Triple-negative | 8 | 0.61 | 0.83 (0.41–1.69) | 0.25 | 0.51 | |
ER-negative | 6 | 0.38 | 0.79 (0.46–1.34) | 0.78 | 0.45 | |
ER-positive | 7 | 0.85 | 1.04 (0.72–1.51) | 0.26 | 0.33 | |
Relative intake of fat | Overall | 4 | 0.68 | 0.91 (0.57–1.44) | 0.13 | 0.13 |
Luminal A | 4 | 0.54 | 0.86 (0.52–1.40) | 0.16 | 0.17 | |
Luminal B | 4 | 0.83 | 1.17 (0.29–4.80) | 0.47 | 0.15 | |
Luminal B HER2-negative | 4 | 0.52 | 0.74 (0.29–1.87) | 0.13 | 0.15 | |
HER2-positive | 4 | 0.16 | 0.51 (0.20–1.30) | 0.76 | 0.94 | |
Triple-negative | 4 | 0.15 | 1.50 (0.87–2.58) | 0.98 | 0.90 | |
ER-negative | 4 | 0.12 | 1.40 (0.92–2.12) | 0.95 | 0.80 | |
ER-positive | 4 | 0.67 | 0.89 (0.50–1.57) | 0.26 | 0.11 | |
Relative intake of protein | Overall | 4 | 8.46 × 10−3 | 0.64 (0.45–0.89) | 0.43 | 0.42 |
Luminal A | 4 | 2.21 × 10−3 | 0.50 (0.32–0.78) | 1.00 | 0.96 | |
Luminal B | 5 | 0.09 | 0.48 (0.21–1.13) | 0.26 | 0.19 | |
Luminal B HER2-negative | 6 | 0.99 | 1.00 (0.56–1.79) | 0.56 | 0.32 | |
HER2-positive | 6 | 0.06 | 0.31 (0.09–1.07) | 0.16 | 0.42 | |
Triple-negative | 5 | 0.87 | 0.94 (0.45–1.95) | 0.79 | 0.95 | |
ER-negative | 5 | 0.07 | 0.60 (0.35–1.04) | 0.70 | 0.44 | |
ER-positive | 4 | 7.91 × 10−4 | 0.49 (0.32–0.74) | 0.54 | 0.34 | |
Relative intake of sugar | Overall | 3 | 0.27 | 1.36 (0.79–2.35) | 0.17 | 0.31 |
Luminal A | 3 | 0.38 | 1.28 (0.74–2.18) | 0.52 | 0.55 | |
Luminal B | 4 | 1.39 × 10−3 | 8.72 (2.31–32.88) | 0.06 | 1.00 | |
Luminal B HER2-negative | 5 | 0.15 | 2.41 (0.72–8.03) | 0.01 | 0.24 | |
HER2-positive | 5 | 9.19 × 10−3 | 4.40 (1.44–13.43) | 0.60 | 0.56 | |
Triple-negative | 3 | 0.94 | 1.04 (0.37–2.89) | 0.95 | 0.84 | |
ER-negative | 4 | 0.90 | 0.96 (0.55–1.68) | 0.73 | 0.62 | |
ER-positive | 4 | 0.21 | 1.26 (0.88–1.82) | 0.70 | 0.59 |
Note: IVW: inverse variance weighted; 95%CI: 95% confidence interval; IVs: instrumental variables; p = p value; outcome = risk of breast cancer.