Table 3.
Risk of organ system-specific congenital malformations in the propensity-score matched cohorts
| Unadjusted OR (95% CI) |
Adjusted OR* (95% CI) |
|
| Any congenital malformation (Q00–Q89) | 1.25 (1.14 to 1.37) | 1.25 (1.14 to 1.37) |
| Q00–07 (congenital malformations of the nervous system) | 1.70 (0.99 to 2.91) | 1.71 (0.99 to 2.91) |
| Q10–Q18 (congenital malformations of the eye, ear, face and neck) | 1.38 (1.07 to 1.78) | 1.38 (1.07 to 1.78) |
| Q20–Q28 (congenital malformations of the circulatory system) | 1.72 (1.47 to 2.01) | 1.72 (1.47 to 2.02) |
| Q30–Q34 (congenital malformations of the respiratory system) | 1.10 (0.57 to 2.12) | 1.10 (0.57 to 2.11) |
| Q35–Q37 (cleft lip and cleft palate) | 0.97 (0.40 to 2.32) | 0.97 (0.40 to 2.32) |
| Q38–Q45 (other congenital malformations of the digestive system) | 0.90 (0.76 to 1.07) | 0.90 (0.76 to 1.07) |
| Q50–Q56 (congenital malformations of the genital organs) | 0.93 (0.63 to 1.39) | 0.93 (0.63 to 1.38) |
| Q60–Q64 (congenital malformations of the urinary system) | 1.08 (0.72 to 1.62) | 1.07 (0.71 to 1.62) |
| Q65–Q79 (congenital malformations and deformations of the musculoskeletal system) | 1.17 (0.95 to 1.43) | 1.17 (0.95 to 1.43) |
| Q80–Q89 (other congenital malformations) | 1.04 (0.62 to 1.72) | 1.04 (0.62 to 1.72) |
ORs and 95% CIs are shown. The control group was selected after matching for age, parity, hypertension, diabetes before pregnancy and year of delivery.
*Adjusted for age, parity, hypertension, diabetes and neonatal sex.
CI, confidence interval; OR, odds ratio.