Table 2.

Cox proportional hazards analysis for all-cause mortality

	Unadjusted HR (95% CI)	Adjusted HR* (95% CI)
Global frailty
Non-frail	1	1
Pre-frail	1.94 (1.84 to 2.04)	1.51 (1.43 to 1.59)
Frail	4.26 (3.97 to 4.57)	2.42 (2.25 to 2.60)
Regional frailty
Non-frail	1	1
Pre-frail	1.75 (1.67 to 1.84)	1.31 (1.24 to 1.37)
Frail	3.48 (2.24 to 3.73)	1.91 (1.77 to 2.06)

n=125 253 for unadjusted analysis, n=120 658 after adjustment for covariates.

*Covariates adjusted for are age, sex, education, smoking status, alcohol consumption and morbidity count.