Figure 1.
Sequences of the hTERT core promoter and consensus motifs for factor binding sites. The start site of transcription is shown by an arrow. The –1 indicates the first nucleotide 5′ to the start site of transcription, while 1 indicates the first nucleotide of the mRNA. The published cDNA sequence is shown in italics. The initiating ATG codon is shown in bold. The E-box is boxed and the Sp1 consensus motifs are underlined. The sequences which were mutated in the functional analyses of cis elements are indicated by asterisks, above which substituted sequences are indicated.