Table 1.

Neuronutritional interventions for preventive migraine management.

The Molecular Target of Neuronutrition	Neuronutritional Interventions
	Dietary Patterns	Nutrients
Mitochondrial dysfunction and metabolic control	Low Glycemic Index Diet [118] Low-fat diet [119] Ketogenic diet [120] EPA 1 + DHA 2 (1.5 g/day) and reduction in omega-6 in the diet [121]	CoQ10 3 (400 mg/day) [122] - CoQ10 (30 mg/day) + L-carnitine (500 mg/day) [123] Riboflavin (400 mg/day) [124] CoQ10 (150 mg/day), riboflavin (400 mg/day), magnesium (600 mg/day) [125] Omega-3 (EPA (400 mg/day) + DHA (350 mg/day)) [126]
Gut–brain axis disturbance	Elimination diet based on immunological testing (IgG+ products) [127] Gluten-free diet [128] Plant-based diet [129]	Multispecies probiotics (Bifidobacterium and Lactobacterium) [130]
Neuroepigenetics modifications	Epigenetic diet (a diet rich in methyl-donor nutrients) [131]	B6 (25 mg/day) + B9 (2 mg/day) + B12 (400 mcg/day) [132] Curcumin (1 g/day) [133]
CGRP 4 levels and CGRP receptor activity	MIND 5-diet [134]	Ginger extract (600 mg/day) [135] Magnesium citrate (600 mg/day) [136] Vitamin D (2000 IU/day) [137] Melatonin (3 mg/day) [138]

¹ EPA—Eicosapentaenoic acid. ² DHA—Docosahexaenoic acid. ³ CoQ10—Coenzyme Q10. ⁴ CGRP—calcitonin gene-related peptide. ⁵ MIND—Mediterranean–DASH Intervention for Neurodegenerative Delay.