Table 3.

Changes to reach and implementation

	Estimate	Standard error	p Value
Hypothesis 1: Shortened patient portal recruitment messages and shortening the consent form will increase the rate of recruitment messages viewed (Reach)
Change pre-and post-shortened MyChart message	+0.09	0.03	0.01
Change pre- and post-shortened consent	+0.03	0.03	0.34
Hypothesis 2: Calling individuals who express interest via patient portal message, shortening the MyChart recruitment message, and shortening the consent form will increase the rate of enrollment (Reach)
Change pre- and post-calling individuals	+0.01	0.02	0.54
Change pre-and post-shortened MyChart message	−0.02	0.03	0.58
Change pre- and post-shortened consent	−0.03	0.02	0.14
Hypothesis 3: Clinical enhancements will increase the rate of DNA samples collected (implementation)
Change pre- and post-clinical enhancements	+0.06	0.16	0.69
*Changes are based on differences between the model-based estimates 7 days prior to and 7 days after the adaptation initiation.