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. 2023 May 30;19(5):e1011219. doi: 10.1371/journal.ppat.1011219

Fig 3. Rectal mucosal microbiome composition in YMSM with and without STI.

Fig 3

(A) Representative bar plot of the top 10 phyla identified by 16S rRNA sequencing from rectal mucosal specimens of the 86 participants with concordant clinical diagnostic assay and 16S microbiome sequencing STI results. (B) Representative bar plot of the top 10 genera identified by 16S rRNA sequencing from rectal mucosal specimens of the 86 participants with concordant clinical diagnostic assay and 16S microbiome sequencing STI results. (C) Bray-Curtis and (D) Jaccard measures of beta diversity, both measured by PERMANOVA, both demonstrated significant differences between the microbiome composition of YMSM with and without STI. Purple dots represent STI-positive YMSM; green dots represent STI-negative YMSM. (E & F) Presence-absence analyses identified 11 genera with a significantly different (FDR<10%) probability of presence between the two groups. STIpos = YMSM with asymptomatic rectal bacterial STI; STIneg = YMSM without asymptomatic rectal bacterial STI.