Table 1.

Therapeutic Targets in AML

Type of Target	Targets
Genetic Targets	Fusion Oncoproteins, FLT3, IDH1/2, p53, KIT
Targets involved in apoptosis	BCL2, MCL-1, BCL-XL, MDM2
Signaling molecules or nuclear receptors	RAS pathway, SYK, RARα
Epigenetic regulators	Menin, DOT1L
Surface proteins and/or molecules involved in immune signaling	Smoothened, CD33, CD123, CD47, SIRPα, AXL, TIM-3, CLL-1, PD-1/PD-L1, and CTLA-4 axes
Transcription factors and other molecules subject to targeted protein degradation	EZH2, GSPT1