Table 2.
Prenatal specific-gravity-corrected organophosphate ester metabolite distribution in the nested study population within the Norwegian mother, father, and child cohort study, 2004–2008.a
| Exposure | Geometric mean (SD)b | Min | 25% | 50% | 75% | Max | LOD | %≥LOD | LOQ | %≥LOQ |
|---|---|---|---|---|---|---|---|---|---|---|
| DPhP (ng/mL) | 0.03 | 0.10 | ||||||||
| Preschool ADHD (N = 262) | 0.49 (2.94) | <LOD | 0.30 | 0.50 | 0.95 | 38.14 | 96.6% | 92.4% | ||
| Typically developing (N = 78) | 0.45 (3.45) | <LOD | 0.20 | 0.44 | 0.82 | 16.17 | 97.4% | 93.6% | ||
| Weighted population (N = 310) | 0.45 (3.24) | <LOD | 0.21 | 0.44 | 0.82 | 38.14 | 97.8% | 92.5% | ||
| DnBP (ng/mL) | 0.07 | 0.20 | ||||||||
| Preschool ADHD (N = 262) | 0.27 (2.18) | <LOD | 0.18 | 0.26 | 0.38 | 11.20 | 95.4% | 67.6% | ||
| Typically developing (N = 78) | 0.20 (2.06) | <LOD | 0.14 | 0.22 | 0.35 | 0.67 | 87.2% | 53.9% | ||
| Weighted population (N = 310) | 0.23 (2.06) | <LOD | 0.15 | 0.23 | 0.37 | 11.20 | 89.5% | 59.5% | ||
| BBOEP (ng/mL) | 0.07 | 0.20 | ||||||||
| Preschool ADHD (N = 262) | 0.08 (2.00) | <LOD | <LOD | <LOD | 0.14 | 0.86 | 44.7% | 13.0% | ||
| Typically developing (N = 78) | 0.09 (2.17) | <LOD | <LOD | <LOD | 0.15 | 1.07 | 47.4% | 19.2% | ||
| Weighted population (N = 310) | 0.09 (2.08) | <LOD | <LOD | <LOD | 0.15 | 1.07 | 46.2% | 17.03% | ||
| BDCIPP (ng/mL) | 0.17 | 0.50 | ||||||||
| Preschool ADHD (N = 262) | 0.17 (2.42) | <LOD | <LOD | <LOD | <LOD | 17.24 | 21.0% | 11.1% | ||
| Typically developing (N = 78) | 0.17 (2.00) | <LOD | <LOD | <LOD | 0.18 | 2.67 | 25.6% | 10.3% | ||
| Weighted population (N = 310) | 0.16 (1.91) | <LOD | <LOD | <LOD | <LOD | 17.24 | 23.6% | 9.75% |
Concentrations were expressed to three significant digits.
Weighted population was created using inverse probability of selection weights to account for oversampling of ADHD cases.
aStudy enrollment occurred through January 2008; however, no study participants in this subpopulation were enrolled in January 2008.
bVariables below the LOD were imputed using LOD/s.
min indicates minimum; max, maximum; ng/mL, nanograms per milliliter.